Cyclosporin A SGT 가 세포주의 성장과 증식에 미치는 영향
The Effect of Cyclosporine A on The Proliferation and Differentiation of SGT Cell Line
이종헌,
소속 상세정보
이종헌 ( Lee Chong-Heon ) - 단국대학교 치과대학 구강병리학교실
KMID : 0829220090330060347
Abstract
Cyclosporine A (Cs A) which is a highly lipophilic cyclic undecapeptide mainly used for its immunosuppressive properties exert a wide spectrum of biological activities including fungicidal antiproliferactive, anti-inflammatory and chemotherapuetic effects. Human salivary gland adenocarcinoma is very aggressive characteristics, which is need to get the effective chemotherapuetic methods. Subconfluent SGT cell cultures have been treated with CsA at in vivo relevant concentrations for 24h. MTT assay for cellular proliferation of cultured SGT cell line has been performed and TGase 1 activity assay for cellular differentiation has been detected in the CsA-treated samples. It suggested that CsA could have an inhibitory effect in the proliferation of SGT cell line but no in the differentiation.
키워드
Cyclosporine A; Proliferation; Differentiation; SGT Cell Line
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